The Rockefeller University Proteomics Resource Center

Mass Spectrometry Instrumentation

Mass spectrometers at the Center:

  • Thermo LTQ-Orbitrap is the state of art mass spectrometer based on the fast and the highly sensitive LTQ XLTM linear ion trap and the Orbitrap technology. This Fourier Transform Mass spectrometer supports a wide range of applications from metabolite identification to proteomic analysis. The combination of LTQ-Orbitrap and an integrated Dionex 3000 capillary/nano HPLC system is a robust workhorse for protein and compound identification with parts per million mass accuracy.

  • Applied Biosystems QSTAR XL tandem mass spectrometer with the hybrid quadrupole time-of-flight configuration. It is designed for protein identification and characterization of posttranslational modifications and it offers the option to interface with nano/capillary-HPLC, nanospray, and MALDI plate. Information Dependent Acquisition (IDA) software allows automatic acquisition of MS and MS/MS data for analysis of complex mixtures. 

  • ThermoFinnigan LTQ is the benchmark ion trap mass spectrometer for rapid metabolite structural elucidation and peptide sequence determination.  The combination of LTQ and an integrated Dionex 3000 capillary/nano HPLC system is a robust workhorse for protein identification.

  • Applied Biosystems DE-STR MALDI-TOF mass spectrometer.  It delivers high sensitivity and resolution as well as unparalleled mass accuracy for determination of molecular weights of proteins at sub-picomole levels and of peptides at femtomole levels. The instrument is equipped with delayed extraction (DE) capability, and can perform post source decay (PSD) analysis.

 

 

This page last updated on July 17, 2008

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© 2007 The Proteomics Resource Center, The Rockefeller University 1230 York Avenue. New York, NY 10065